Biophotonics, Neurosciences and Optometry
This theme brings together the expertise of optical physicists and neurobiologists in research areas spanning Biophotonics, Neurosciences and Optometry.
Biophotonics
We develop methods to measure the dynamics of biological processes across multiple scales — from individual biomolecules to cell assemblies — with high spatiotemporal resolution (a few nanometers, a few milliseconds).
Our research focuses specifically on the one hand on real-time tracking of biological processes at the single-system level, and on the other hand on measuring neuronal activity at the scale of individual cells (e.g., axonal transport) or neuronal assemblies (e.g., synaptic connectivity) in biological systems maintained in our laboratory.
For these studies, we design and utilize a wide range of optical microscopes, including custom-developed systems such as total internal reflection fluorescence (TIRF) microscopes for single-molecule studies or tracking individual nanoparticles, as well as light-sheet microscopes. In addition, we employ optical sensors to monitor neuronal electrical activity, leveraging either NV centers in diamond or doped ferroelectric nanocrystals.
Neurosciences
This theme brings together biologists and physicists studying the mechanisms underlying central nervous system diseases, such as Alzheimer’s and myotonic dystrophy type 1 (DM1). Using advanced electrophysiology and fluorescence imaging techniques on murine models, they investigate synaptic dysfunction—a key factor in these disorders. The synapse, a microscopic structure essential for neuronal communication, houses neurotransmitter receptors and brain signaling pathways. Understanding cellular and synaptic alterations is critical for identifying new therapeutic strategies.
Optometry
Our team conducts research in physiological optics, focusing on the visual performance of the human eye. We are developing a method to simulate retinal image quality. Our work also explores the mechanisms of accommodation and their impact on vision, particularly visual fatigue.
