Publications

Affichage des publications 351 à 360 sur 696 au total

Neurobiologie

Interplay between 5-HT4 receptors and GABAergic system within CA1 hippocampal synaptic plasticity

The type 4 serotonin receptor (5-HT4R) is highly involved in cognitive processes such as learning and memory. Behavioral studies have shown a beneficial effect of its activation and conversely reported memory impairments by its blockade. However,…

Pierre Lecouflet, Candice Roux, B Potier, Marianne Leger, Elie Brunet, Jean-Marie Billard, Pascale Schumann- Bard, Thomas Freret

Cerebral Cortex -

Sciences cognitives

Dopaminergic neuromodulation of prefrontal cortex activity requires the NMDA receptor coagonist d-serine

Prefrontal control of cognitive functions critically depends upon glutamatergic transmission and N-methyl D-aspartate (NMDA) receptors, the activity of which is regulated by dopamine. Yet whether the NMDA receptor coagonist d -serine is implicated…

Glenn Dallérac, Xia Li, Pierre Lecouflet, Nadège Morisot, Silvia Sacchi, Rachel Asselot, Thu Ha Pham, Brigitte Potier, David Watson, Staffan Schmidt, Grégoire Levasseur, Pascal Fossat, Andrey Besedin, Jean-Michel Rivet, Joseph Coyle, Ginetta Collo, Loredano Pollegioni, Jan Kehr, Micaela Galante, Kevin Fone, Alain Gardier, Thomas Freret, Angelo Contarino, Mark Millan, Jean-Pierre Mothet

Proceedings of the National Academy of Sciences of the United States of America -

Neurobiologie

Astrocytic VMAT2 in the developing prefrontal cortex is required for normal grooming behavior in mice

Abstract Astrocytes control synaptic activity by modulating peri-synaptic concentrations of ion and neurotransmitters including dopamine and, as such, can be critically involved in the modulation of some aspect of mammalian behavior. Here we report…

Francesco Petrelli, Tamara Zehnder, Luca Pucci, Corrado Cali, Bianca Maria Bondiolotti, Alicia Molinero Perez, Glenn Dallerac, Nicole Déglon, Bruno Giros, Fulvio Magara, Lorenzo Magrassi, Jean-Pierre Mothet, Linda Simmler, Paola Bezzi

Neurosciences

P2X7-deficiency improves plasticity and cognitive abilities in a mouse model of Tauopathy

Alzheimer's disease is the most common form of dementia characterized by intracellular aggregates of hyperphosphorylated Tau protein and extracellular accumulation of amyloid β (Aβ) peptides. We previously demonstrated that the purinergic receptor…

Kevin Carvalho, Elodie Martin, Aurélia Ces, Nadège Sarrazin, Pauline Lagouge-Roussey, Caroline Nous, Leyna Boucherit, Ihsen Youssef, Annick Prigent, Emilie Faivre, Sabiha Eddarkaoui, Thibaut Gauvrit, Didier Vieau, Susana Boluda, Vincent Huin, Bertrand Fontaine, Luc Buée, Benoît Delatour, Patrick Dutar, Florian Sennlaub, Xavier Guillonneau, David Blum, Cécile Delarasse

Progress in Neurobiology -